| 中文名稱 | 鳥氨酸脫羧酶抗體 |
| 別 名 | Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 2; DCOR_HUMAN; Ornithine decarboxylase 1; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC. |
| 研究領域 | 腫瘤 信號轉導 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 51kDa |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ODC:321-461/461 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa. Subunit: Homodimer. Post-translational modifications: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SWISS: Q9BQT8 Gene ID: 4953 Database links: Entrez Gene: 281365 Cow Entrez Gene: 4953 Human Entrez Gene: 18263 Mouse Entrez Gene: 414408 Pig Entrez Gene: 24609 Rat Omim: 165640 Human SwissProt: P27117 Cow SwissProt: P11926 Human SwissProt: P00860 Mouse SwissProt: P09057 Rat Unigene: 7133 Cow Unigene: 467701 Human Unigene: 34102 Mouse Unigene: 874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 鳥氨酸脫羧酶為多胺生物合成途徑中的第一個限速酶 (催化合成多胺的第一步反應 ,即催化L -鳥氨酸脫羧生成腐胺 ) ,具有超常轉變率和對于刺激的迅速反應性。 多胺廣泛存在于生物體的各種細胞和組織中 ,是一種重要的代謝調控物質 ,它可直接與DNA相互作用 ,調節DNA構象 ,并參與RNA及蛋白質的合成 ,與細胞增殖、分化密切相關。經研究表明 ,哺乳動物細胞增殖體現出完全的多胺依賴性。ODC主要存在于胞漿中。 |
| 產品圖片 |  Sample: Kidney(Mouse) lysate at 30ug;Primary: Anti-ODC(bs-1294R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size:51 kD Observed band size:51 kD  Sample:Liver(Mouse) lysate at 30ug;Primary: Anti-ODC(bs-1294R) at 1:300 dilution; Secondary: AP conjugated Goat Anti-Rabbit IgG(bs-0295G-AP) at 1: 5000 dilution; Predicted band size : 51kD Observed band size : 51kD  Sample: Kidney(Mouse) lysate at 30ug;Primary: Anti-ODC(bs-1294R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size:51 kD Observed band size:51 kD  Paraformaldehyde-fixed, paraffin embedded (rat stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODC) Polyclonal Antibody, Unconjugated (bs-1294R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODC) Polyclonal Antibody, Unconjugated (bs-1294R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. |
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