| 中文名稱 | 內涎蛋白/內皮唾液酸蛋白抗體 |
| 別 名 | Tumor endothelial marker 1 precursor; TEM 1; TEM-1; tumor endothelial marker 1; CD248; Endosialin; Tumor endothelial marker 1; CD164L1; MGC119478; MGC119479. CD164 sialomucin-like 1; CD248_HUMAN. |
| 研究領域 | 腫瘤 心血管 細胞凋亡 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TEM 1:251-350/757 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment. Function: May play a role in tumor angiogenesis. Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts. Post-translational modifications: O-glycosylated with sialylated oligosaccharides. May be N-glycosylated. Similarity: Contains 1 C-type lectin domain. Contains 1 EGF-like domain.Contains 1 Sushi (CCP/SCR) domain. SWISS: Q9HCU0 Gene ID: 57124 Database links: Entrez Gene: 57124 Human Entrez Gene: 70445 Mouse Entrez Gene: 293669 Rat Omim: 606064 Human SwissProt: Q9HCU0 Human SwissProt: Q91V98 Mouse Unigene: 195727 Human Unigene: 29597 Mouse Unigene: 38806 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 內皮唾液酸蛋白（CD248）是近年發現的人類腫瘤標記物之一,在人類多種惡性腫瘤組織中異常高表達,內皮唾液酸蛋白對腫瘤細胞生長、血管生成、浸潤及轉移有重要作用。 |
| 產品圖片 |  Sample:Thymus(mouse) Lysate at 40 ug Primary: Anti-TEM1 (bs-2101R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 80 kD Observed band size: 130 kD Sample: spleen(mouse) Lysate at 30 ugPrimary: Anti-TEM1 (bs-2101R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 80 kD Observed band size: 130 kD  Sample:MKN45(Human) Cell Lysate at 30 ug Primary: Anti-TEM1 (bs-2101R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 80 kD Observed band size: 130 kD  Sample:SW480(Human) Cell Lysate at 30 ug 293T(Human) Cell Lysate at 30 ug Primary: Anti-TEM1 (bs-2101R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 80 kD Observed band size: 130 kD  Paraformaldehyde-fixed, paraffin embedded (Human stomach carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TEM1) Polyclonal Antibody, Unconjugated (bs-2101R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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