| 中文名稱 | 白介素-17抗體 |
| 別 名 | Interleukin-17; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL17A; IL-17A; Interleukin 17; Interleukin 17A; Interleukin17; Interleukin17A. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-17:85-150/150 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17. Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Restricted to a subset of activated T-cells. Post-translational modifications: Found both in glycosylated and nonglycosylated forms. Similarity: Belongs to the IL-17 family. SWISS: Q16552 Gene ID: 16171 Database links:
Entrez Gene: 3605 Human Entrez Gene: 16171 Mouse Entrez Gene: 301289 Rat Omim: 603149 Human SwissProt: Q16552 Human SwissProt: Q62386 Mouse SwissProt: Q61453 Rat Unigene: 41724 Human Unigene: 5419 Mouse Unigene: 218513 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白細(xì)胞介素17（IL-17A）是一種來源于活化T淋巴細(xì)胞的細(xì)胞因子,具有較廣泛的生物學(xué)活性,它能夠通過誘導(dǎo)基質(zhì)細(xì)胞產(chǎn)生前炎性細(xì)胞因子和造血細(xì)胞因子參與機(jī)體免疫調(diào)節(jié)及部分炎癥反應(yīng)，因此白細(xì)胞介素IL-17A可能是某些疾病發(fā)生發(fā)展的重要因素之一。Interleukin-17 原稱CTLA-8, 是T細(xì)胞表達(dá)的多肽，參與造血干系統(tǒng)的調(diào)節(jié)，已經(jīng)顯示IL-17促進(jìn)纖維母細(xì)胞產(chǎn)生IL-6，IL-8和G-CSF。 |
| 產(chǎn)品圖片 |  Sample: Intestine (Rat)cell Lysate at 40 ugPrimary: Anti-IL-17(bs-1183R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 15 kD Observed band size: 19kD  Sample:Blood (mouse)cell Lysate at 40 ugPrimary: Anti-IL-17(bs-1183R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 15 kD Observed band size: 19kD Tissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(bs-1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(bs-1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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