| 中文名稱 | 陽離子通道精子相關蛋白2抗體 |
| 別 名 | CTSR2_HUMAN; Cation channel sperm-associated protein 2; CatSper2; CatSper 2; CatSper-2; cation channel sperm-associated protein 2 isoform 2; sperm ion channel; cation channel sperm-associated protein 2; Putative ion channel protein CATSPER2 variant 1; Putative ion channel protein CATSPER2 variant 2; Putative ion channel protein CATSPER2 variant 3; Sperm associated cation channel 2. |
| 研究領域 | 細胞生物 通道蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Sheep, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 細胞定位 | 細胞外基質 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CATSPER2:1-100/530 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Aug 2008]. Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Subunit: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity. Subcellular Location: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. Tissue Specificity: Testis-specific. DISEASE: Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. SWISS: Q8NHT9 Gene ID: 117155 Database links: Entrez Gene: 117155 Human Omim: 607249 Human SwissProt: Q8NHT9 Human Unigene: 662284 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品圖片 |  Sample:Testis(Rat) Lysate at 40 ug Primary: Anti- CATSPER2 (bs-10473R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD Sample:Testis(Rat) Lysate at 40 ug Primary: Anti- CATSPER2 (bs-10473R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD  Sample: testis (Mouse) Lysate at 40 ugPrimary: Anti-CATSPER2(bs-10196R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD Sample: testis (Mouse) Lysate at 40 ugPrimary: Anti-CATSPER2(bs-10196R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD  Sample:Hela (human)Cell Lysate at 40 ug 293T (human)Cell Lysate at 40 ug Primary: Anti-CATSPER2(bs-10473R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD Sample:Hela (human)Cell Lysate at 40 ug 293T (human)Cell Lysate at 40 ug Primary: Anti-CATSPER2(bs-10473R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD  Sample:293T(Human) Cell Lysate at 30 ug Primary: Anti- CATSPER2 (bs-10473R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD Sample:293T(Human) Cell Lysate at 30 ug Primary: Anti- CATSPER2 (bs-10473R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD |
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