Host:Rabbit
Target Protein:ox-LDL
Clonality:Polyclonal
Isotype:IgG
Source:Full length protein from human plasma:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidati vely modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of a therosclerosis but the precise changes in oxidized LDL are not well described. Low-de nsity lipoprotein oxidised with Cu2SO4. When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substan ces it can form plaque, a thick, hard deposit that can clog those arteries. This conditi on is known as atherosclerosis. Oxidized lipoproteins are formed by free radical dam age to lipids that accumulate in macrophages and smooth muscle cells causing foam
cell formation, an initial step in the disease.
Size:100ul(1mg/ml)
Applications:
WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(3ug/Test)
IF(1:100-500)
Cross Reactive Species:Human,Mouse,Rat,Cow,Rabbit.
For research use only. Not intended for diagnostic or therapeutic use
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