Product Details
- Verified Reactivity
- Human
- Reported Reactivity
- Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Primary human Langerhans cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported application (for the relevant formats) includes: blocking the binding of HIV-1 to Langerhans cells1.
- Application References
(PubMed link indicates BioLegend citation) -
- Witte LD, et al. 2007. Nat. Med. 13:367. (Block)
- Product Citations
-
- RRID
- AB_10898115 (BioLegend Cat. No. 352202)
Antigen Details
- Structure
- 40 kD glycoprotein
- Distribution
-
Langerhans cells, dermal CD103-positive dendritic cells, and splenic CD8-positive dendritic cells
- Function
- Binding and processing antigen; capturing, internalizing and degrading HIV
- Ligand/Receptor
- Antigen containing mannose, N-acetyl glucosamine, and fucose
- Cell Type
- Dendritic cells, Langerhans cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Valladeau J, et al. 2000. Immunity 12:71.
2. Mc Dermott R, et al. 2002. Mol. Biol. Cell. 13:317.
3. Mizumoto N, et al. 2004. J. Clin. Invest. 113:701.
4. Witte LD, et al. 2007. Nat. Med. 13:367. - Gene ID
- 50489 View all products for this Gene ID
- UniProt
- View information about CD207 on UniProt.org
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