Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant Mouse IL4Rα encoding the extracellular domain (amino acid residues 26 - 233) was fused to the carboxy-terminal Fc region of human IgG1 via a linker peptide.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Dazzle? 594 under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC – Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PE/Dazzle? 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
- AB_2910298 (BioLegend Cat. No. 144813) AB_2910298 (BioLegend Cat. No. 144814)
Antigen Details
- Structure
- 140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit
- Distribution
-
B cells, T cells, monocytes, and low levels on granulocytes.
- Function
- Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells
- Interaction
- STAT6
- Ligand/Receptor
- IL-4, IL-13
- Cell Type
- B cells, Granulocytes, Monocytes, T cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- Kashiwada M, et al. 2001. J Immunol. 167:6382-7.
- Gilmour J, et al. 2008. J Immunol. 124:437-44.
- Hage T, et al. 1999. Cell. 97:271-81.
- Gene ID
- 16190 View all products for this Gene ID
- UniProt
- View information about CD124 on UniProt.org
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