Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human EPO
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IP - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by?immunoprecipitation. This antibody can be used at 1 - 5 ?g/mL?for immunoprecipitation. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2564245 (BioLegend Cat. No. 662202)
Antigen Details
- Structure
- 165 amino acid protein with a predicted molecular weight of approximately 18 kD. It migrates at approximately 37-57 kD as a result of its glycosylation.
- Distribution
- EPO is primarily expressed in kidney (70-90% of the total EPO) and liver cells. EPO is expressed by hepatocytes, cortical interstitial fibroblasts in ischemic kidneys, astrocytes, and neurons under hypoxic conditions.
- Function
- EPO is the major regulator of differentiation, proliferation, and survival of erythroid progenitors. EPO expression is induced by hypoxia, HIF, and other transcription factors. EPO also plays a role in neuroprotection.
- Interaction
- Erythroid progenitor cells
- Ligand/Receptor
- EpoR (homodimer)
- Cell Type
- Fibroblasts, Neurons
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Shoemaker CB, et al. 1986. Mol. Cell. Biol. 6:849.
2. McDonald JD, et al. 1986. Mol. Cell. Biol. 6:842.
3. Chin K, et al. 2000. Brain Res. Mol. Brain Res. 81:29.
4. Snow JW, et al. 2009. J. Biol. Chem. 284:29310.
5. Kassouf MT, et al. 2010. Genome Res. 2010:20:1064.
6. Paliege A, et al. 2010. Kidney Int. 77:312.
7. Sinclair AM, et al. 2010. Blood 115:4264.
8. Alnaeeli M, et al. 2012. Anat. Res. Int. 2012:953264. - Gene ID
- 2056 View all products for this Gene ID
- UniProt
- View information about EPO on UniProt.org
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