Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Aggrecan produced in 293E cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody works for Western blotting under non-reducing conditions.
- RRID
- AB_2565486 (BioLegend Cat. No. 674902)
Antigen Details
- Structure
- 2415 amino acids with a predicted molecular weight of approximately 250 kD.
- Distribution
-
Chondrocytes and embryonic brain glia.
- Function
- Plays a key role in neural development, glial scar formation, cell adhesion, cell growth, receptor binding, cell migration, and interaction with other extracellular matrix constituents.
- Ligand/Receptor
- Aggrecan is an enzymatic substrate of MMPs and ADAMT11. It interacts with versican, which is a large ECM proteoglycan.
- Biology Area
- Cell Biology, Signal Transduction
- Antigen References
-
1. Doege KJ, et al. 1991. J. Biol. Chem. 266:894.
2. Nap RJ and Szleifer I. 2008. Biophys. J. 95:4570.
3. Roughley P, et al. 2006. Eur. Cell Mater. 11:1.
4. Kiani C, et al. 2002. Cell Res. 12:19-32.
5. Melin Fürst C, et al. 2013. PLoS One 8:e61407. - Gene ID
- 176 View all products for this Gene ID
- UniProt
- View information about Aggrecan on UniProt.org
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