Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- H-Y specific TH Clone OI6
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: induction of proliferation of Vβ8.1+ and Vβ8.2+ T cells1,2 and immunohistochemical staining3.
- Application References
(PubMed link indicates BioLegend citation) -
- Kanagawa OJ. 1988. J. Immunol. Methods 110:169. (Activ)
- Denkers EY, et al. 1986. J. Immunol. 156:1089. (Activ)
- Drescher KM, et al. 2000. Int. Immunol. 12:271. (IHC)
- Huang JR, et al. 2014. J Immunol. 192:1972. PubMed
- Product Citations
-
- RRID
- AB_10641144 (BioLegend Cat. No. 140103) AB_10639942 (BioLegend Cat. No. 140104)
Antigen Details
- Structure
- Members of the immunoglobulin superfamily, Vβ8.1 and 8.2 are variants of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
- Distribution
- Expressed in a subset of TCR αβ+ T cells
- Function
- Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune response
- Ligand/Receptor
- MHC-Peptide complex
- Cell Type
- T cells
- Biology Area
- Immunology, Adaptive Immunity
- Molecular Family
- TCRs
- Antigen References
-
1. Marrack P, et al. 2008. Annu. Rev. Immunol. 26:171.
2. Acha-Orbea H and MacDonald HR. 1995. Annu. Rev. Immunol. 13:459.
3. Sim GK and Augustin AA. 1985. Cell 42:89.
4. Mami-Chouaib F, et al. 2002. Immunol. Rev. 188:114. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR V beta 8 on UniProt.org
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