Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Murine T cell hybridoma 2HB51.8
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: Induction of proliferation of V?5.1+ and V?5.2+ T cells2, 3 and in vivo depletion of V?5+ T cells4.
- Application References
(PubMed link indicates BioLegend citation) -
- Kanagawa O, et al. 1991. J. Immunol. 147:1307. (FC)
- Kanagawa O, et al. 1992. J. Immunol. 149:9. (Activ)
- Woodland DL, et al. 1993. J. Exp. Med. 177:433. (Activ)
- Gelber C, et al. 1992. Cancer Res. 52:6507. (Deplete)
- Product Citations
-
- RRID
- AB_10897800 (BioLegend Cat. No. 139505) AB_10933250 (BioLegend Cat. No. 139506)
Antigen Details
- Structure
- Member of the immunoglobulin superfamily, Vβ5.1and 5.2 are variants of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
- Distribution
-
Expressed on a subset of TCR αβ+ T cells.
- Function
- Recognition of peptides presented by the MHC molecules, responsible for T cell mediated immune responses.
- Ligand/Receptor
- MHC-Peptide complex
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Marrack P, et al. 2008. Annu. Rev. Immunol. 26:171.
2. Sim GK and Augustin AA. 1985. Cell 42:89.
3. Mami-Chouaib F, et al. 2002. Immunol. Rev. 188:114. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR Vb5.1, 5.2 on UniProt.org
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