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Brilliant Violet 711™ anti-human CD3 Antibod

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Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 711? excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex.

Clone OKT3 can block the binding of clones SK7 and UCHT1.4 The OKT3 antibody is able to induce T cell activation. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections and activation of T cells. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 317304). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 317326) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  3. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  4. Li B, et al. 2005. Immunology 116:487.
  5. Jeong HY, et al. 2008. J. Leuckocyte Biol. 83:755. PubMed
  6. Alter G, et al. 2008. J. Virol. 82:9668. PubMed
  7. Manevich-Mendelson E, et al. 2009. Blood 114:2344. PubMed
  8. Pinto JP, et al. 2010. Immunology. 130:217. PubMed
  9. Biggs MJ, et al. 2011. J. R. Soc. Interface. 8:1462. PubMed
Product Citations
  1. Mo Y, et al. 2022. Front Immunol. 12:799896. PubMed
  2. Pizzolla A, et al. 2021. Methods Mol Biol. 2265:529. PubMed
  3. Kritikou J, et al. 2016. Sci Rep. 6:30636. PubMed
  4. Swadling L, et al. 2020. Cell Rep. 30:687. PubMed
  5. Zhou R, et al. 2020. Immunity. S1074-7613(20)30333-2.. PubMed
  6. Karim F, et al. 2021. Elife. 10:. PubMed
  7. Klichinsky M, et al. 2020. Nat Biotechnol. 38:947. PubMed
  8. Gruber T, et al. 2020. JCI Insight. 5:00. PubMed
  9. Pellett Madan R, et al. 2020. Clin Transplant. 34:e14021. PubMed
  10. Powell WE, et al. 2018. Diabetologia. 61:1794. PubMed
  11. Lee E, et al. 2019. Front Microbiol. 1.954166667. PubMed
  12. Izadi D, et al. 2019. Sci Adv. 5:eaay0370. PubMed
  13. Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
  14. Gyurdieva A, et al. 2022. Nat Commun. 13:5296. PubMed
  15. Paul S, et al. 2021. Sci Transl Med. 13:. PubMed
  16. Collier DA, et al. 2021. Nature. 596:417. PubMed
  17. D'Antoni ML, et al. 2019. Front Immunol. 2.353472222. PubMed
  18. Willmann K, et al. 2014. Nat Commun. 5:5360. PubMed
  19. D’Antoni ML, et al. 2018. J Acquir Immune Defic Syndr. 79:108. PubMed
  20. Darcis G, et al. 2020. Cell Rep. 30:2284. PubMed
  21. Joyner CJ, et al. 2022. Life Sci Alliance. 5:. PubMed
RRID
AB_11219592 (BioLegend Cat. No. 317327) AB_2562907 (BioLegend Cat. No. 317328)

Antigen Details

Structure
Ig superfamily, the subunits CD3γ, CD3δ, CD3ζ (CD247) and TCR (α/β or γ/δ) form the CD3/TCR complex, 20 kD
Distribution

Mature T and NK T cells, thymocyte differentiation

Function
Antigen recognition, signal transduction, T cell activation
Ligand/Receptor
Peptide antigen bound to MHC
Cell Type
NKT cells, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Barclay N, et al. 1993. The Leucocyte FactsBook. Academic Press. San Diego.
  2. Beverly P, et al. 1981. Eur. J. Immunol. 11:329.
  3. Lanier L, et al. 1986. J. Immunol. 137:2501.
Gene ID
916 View all products for this Gene ID
UniProt
View information about CD3 on UniProt.org
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