日本精久视频69视频在线播放_国产精品狼人色视频一区_1024手机基地你懂的日韩人妻_急救护士美国满天星全名_亚洲狼人香蕉香蕉在线28_亚洲一级电影在线观看_国产a国产高清免费_亚洲情s网站大全_日韩美女日批爽爽爽_欧美三级一区二区在线观看

您好，歡迎光臨上海雅吉生物商城！
工作時間：9:00-18:00
全國服務(wù)熱線：021-34661276

Purified anti-human CD3 Antibody

訂購數(shù)量：
規(guī)格
價格庫存
訂購熱線：021-34661276
我要詢價
  • 商品詳情
  • 售后服務(wù)
  • 相關(guān)文獻(xiàn)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex.

Clone OKT3 can block the binding of clones SK7 and UCHT1.4 The OKT3 antibody is able to induce T cell activation. Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections and activation of T cells. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 317304). For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 317326) with a lower endotoxin limit than standard LEAF? purified antibodies (Endotoxin <0.01 EU/?g).

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  2. Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York.
  3. Barclay N, et al. 1997. The Leucocyte Antigen Facts Book. Academic Press Inc. San Diego.
  4. Li B, et al. 2005. Immunology 116:487.
  5. Jeong HY, et al. 2008. J. Leuckocyte Biol. 83:755. PubMed
  6. Alter G, et al. 2008. J. Virol. 82:9668. PubMed
  7. Manevich-Mendelson E, et al. 2009. Blood 114:2344. PubMed
  8. Pinto JP, et al. 2010. Immunology. 130:217. PubMed
  9. Biggs MJ, et al. 2011. J. R. Soc. Interface. 8:1462. PubMed
Product Citations
  1. Mousset CM, et al. 2018. Oncoimmunology. 7:e1488565. PubMed
  2. Jeong H, et al. 2008. J Leukoc Biol. 83:755. PubMed
  3. Biggs M, et al. 2011. J R Soc Interface. 1.348611111. PubMed
  4. Mammadli M, et al. 2021. Clin Transl Med. 11:e625. PubMed
  5. Blas-Rus N, et al. 2016. Nat Commun. 7: 11389. PubMed
  6. Mehta N, et al. 2020. Sci Rep. 10:15171. PubMed
  7. Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
  8. Li G, et al. 2021. Oncoimmunology. 10:1983306. PubMed
  9. Weinhage T, et al. 2020. J Immunol. 205:56. PubMed
  10. Berkson JD, et al. 2020. Immunohorizons. 4:14. PubMed
  11. Barzilai S, et al. 2017. Cell Rep. 18(3):685-699. PubMed
  12. Bae EA, et al. 2018. Cancer Res. 78:5315. PubMed
  13. Liang J, et al. 2017. Nat Commun. 8:15732. PubMed
  14. Ghosh S, et al. 2020. Cell Reports. 30(10):3434-3447. PubMed
  15. Willing A, et al. 2018. J Immunol. 200:974. PubMed
  16. Bluhm J, et al. 2018. Mol Ther. 26:1906. PubMed
  17. Yarzabek B et al. 2018. eLife. 7 pii: e34961. PubMed
  18. Lang C, Wang J, and Chen L 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.09.030. PubMed
  19. Fronik P, et al. 2021. J Med Chem. 64:12132. PubMed
  20. Amiad-Pavlov D, et al. 2021. Sci Adv. 7: . PubMed
  21. Nissim L et al. 2017. Cell. 171(5):1138-1150 . PubMed
  22. García–Ortiz A, et al. 2017. PLoS Biol. 15:e2000653. PubMed
  23. Kujawski M, et al. 2019. BMC Cancer. 1.404166667. PubMed
  24. Willimsky G, et al. 2021. Elife. 10:. PubMed
  25. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  26. Nathan A, et al. 2021. Cell. 184(17):4401-4413.e10. PubMed
  27. Kaufmann M, et al. 2021. Med. 2(3):296-312.e8. PubMed
  28. Holbrook AK, et al. 2019. Physiol Rep. 7:e14234. PubMed
  29. Winkler M, et al. 2017. PLoS One.. 10.1371/journal.pone.0182427. PubMed
  30. Dilchert J, et al. 2022. Antibodies (Basel). 11:. PubMed
  31. Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed
  32. Xiong Y, et al. 2019. J Immunol. 203:3023. PubMed
  33. Kessel C, et al. 2017. Arthritis Rheumatol. 69:1480. PubMed
  34. Fu Z, et al. 2021. Acta Pharm Sin B. 11:3925. PubMed
  35. Wilson AS, et al. 2022. Nat Commun. 13:528. PubMed
  36. Jilg N, et al. 2020. J Infect Dis. 222:1837. PubMed
  37. Hu X, et al. 2021. British Journal of Pharmacology. 178(6):1445-1458. PubMed
  38. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  39. Li L, et al. 2020. J Transl Med. 18:363. PubMed
  40. Broos K, et al. 2019. Cancers (Basel). 11. PubMed
  41. Zhao R, et al. 2018. Oncoimmunology. 8:e1509173. PubMed
  42. Li H, et al. 2020. Front Immunol. 11:1777. PubMed
  43. Hsu CY, et al. 2020. Frontiers in Immunology. 11:574839. PubMed
  44. Walk J, et al. 2020. Front Immunol. 2.405555556. PubMed
  45. Johnston HE, et al. 2018. Mol Cell Proteomics. 1.247222222. PubMed
  46. Thomi R, et al. 2017. Br J Dermatol.. 10.1111/bjd.15458. PubMed
  47. Kim G, et al. 2021. J Infect Dis. 224:1861. PubMed
  48. Herati RS, et al. 2021. Cell Reports Medicine. 2(5):100262. PubMed
  49. Mayer KE, et al. 2019. Theranostics. 4.548611111. PubMed
  50. Tripathi T, et al. 2019. Immunohorizons. 0.201388889. PubMed
  51. Alter G, et al. 2008. J Virol. 82:9668. PubMed
  52. Gurusamy M, et al. 2021. Nat Commun. 12:6798. PubMed
  53. Zu?iga J, et al. 2020. Int J Infect Dis. 94:4. PubMed
  54. Wang Q, et al. 2020. J Immunother Cancer. 8:. PubMed
  55. Glud EN, et al. 2022. Br J Cancer. Online ahead of print. PubMed
  56. Pinto J, et al. 2010. Immunology. 130:217. PubMed
  57. Auladell M, et al. 2019. Clin Transl Immunology. 8:e01090. PubMed
  58. Seo N, et al. 2018. Nat Commun. 9:435. PubMed
  59. Qiu H, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.08.036. PubMed
  60. Jin Y, et al. 2017. Int Immunopharmacol. . 10.1016/j.intimp.2017.10.009. PubMed
  61. Schoknecht T, et al. 2017. J Leukoc Biol. 101:589. PubMed
  62. Escudero–Pérez B, et al. 2019. JCI Insight. 4:e126070. PubMed
  63. Guo J, et al. 2022. J Immunother Cancer. 10:. PubMed
  64. Wiedeman AE, et al. 2020. J Clin Invest. 130:480. PubMed
  65. Rivera-Cruz CM, et al. 2022. Cytotherapy. Online ahead of print. PubMed
  66. Park S, et al. 2020. Biosens Bioelectron. 112389:165. PubMed
  67. Henrick BM, et al. 2021. Cell. . PubMed
  68. Zavidij O, et al. 2020. Nat Cancer. 0.384027778. PubMed
  69. Manevich-Mendelson E, et al. 2009. Blood. 114:2344. PubMed
  70. Caielli S, et al. 2019. Nat Med. 25:75. PubMed
  71. Ardain A, et al. 2019. Nature. 570:528. PubMed
  72. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  73. Singh AK, et al. 2017. Front Immunol. 0.513888889. PubMed
  74. Lee YS, et al. 2021. J Immunother Cancer. 9:. PubMed
  75. Bacot SM, et al. 2020. Int J Mol Sci. 21:. PubMed
  76. Hirama T, et al. 2021. JCI Insight. 6:. PubMed
  77. Levin SD, et al. 2020. Front Immunol. 10:3086. PubMed
  78. Pawlak EN, et al. 2018. Retrovirology. 15:6. PubMed
  79. Meng Q, et al. 2018. Sci Rep. 8:17079. PubMed
  80. Boutboul D, et al. 2018. J Clin Invest. 128:3071. PubMed
  81. Chevalier MF, et al. 2017. J Clin Invest. 127:2916. PubMed
  82. Carriche GM, et al. 2021. J Allergy Clin Immunol. 147:335. PubMed
  83. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  84. Benabdallah B, et al. 2019. Front Immunol. 10:2580. PubMed
  85. Sneddon S, et al. 2020. Oncoimmunology. 9:1684713. PubMed
  86. Moosmann C, et al. 2022. STAR Protoc. 3:101031. PubMed
  87. Cassioli C, et al. 2021. Front Cell Dev Biol. 9:673446. PubMed
  88. Müller TR, et al. 2021. Cell Rep Med. 2:100374. PubMed
  89. Crome SQ, et al. 2017. Nat Med. 1.213888889. PubMed
  90. Hashimoto M, et al. 2017. Int J Inflam. 2017:1324735. PubMed
  91. Siegers GM, et al. 2020. Front Immunol. 1.352083333. PubMed
  92. Garcia de Moura R, et al. 2021. Front Immunol. 12:632667. PubMed
  93. Naranbhai V, et al. 2022. Cell. . PubMed
  94. Yang J, et al. 2020. Nat Commun. 11:4402. PubMed
  95. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  96. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  97. He Y, et al. 2021. eLife. 10:00. PubMed
  98. Yin Y, et al. 2017. J Allergy Clin Immunol. 139:1701. PubMed
  99. Malenica I, et al. 2021. Nat Commun. 12:5209. PubMed
  100. Liu Z, et al. 2017. Oncotarget. 8:53518. PubMed
  101. Terzuoli E, et al. 2019. Cancers (Basel). 1.821527778. PubMed
  102. Akhand SS, et al. 2020. Cancer Immunol Res. 8:1542. PubMed
  103. Welch JL, et al. 2020. FEBS Lett. 594:695. PubMed
  104. Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed
  105. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
  106. Chiou SH, et al. 2021. Immunity. 54:586. PubMed
  107. Shalata W, et al. 2021. Cancers (Basel). 13: . PubMed
RRID
AB_571926 (BioLegend Cat. No. 317301) AB_571927 (BioLegend Cat. No. 317302)

Antigen Details

Structure
Ig superfamily, the subunits CD3γ, CD3δ, CD3ζ (CD247) and TCR (α/β or γ/δ) form the CD3/TCR complex, 20 kD
Distribution

Mature T and NK T cells, thymocyte differentiation

Function
Antigen recognition, signal transduction, T cell activation
Ligand/Receptor
Peptide antigen bound to MHC
Cell Type
NKT cells, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Barclay N, et al. 1993. The Leucocyte FactsBook. Academic Press. San Diego.
  2. Beverly P, et al. 1981. Eur. J. Immunol. 11:329.
  3. Lanier L, et al. 1986. J. Immunol. 137:2501.
Gene ID
916 View all products for this Gene ID
UniProt
View information about CD3 on UniProt.org
我要詢價
*聯(lián)系方式：
(可以是QQ、MSN、電子郵箱、電話等，您的聯(lián)系方式不會被公開)
*內(nèi)容：


微信客服
掃一掃立即咨詢


微信客服
掃一掃立即咨詢

銷售電話：

021-34661275

021-34661276

15301693058