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APC anti-human CD4 Antibody

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Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human peripheral T cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

The OKT4 antibody binds to the D3 domain of CD4 and does not block HIV binding.　Additional reported applications (for the relevant formats) include: immunohistochemistry of frozen sections and blocking of T cell activation. This clone was tested in-house and does not work on formalin fixed paraffin-embedded (FFPE) tissue. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 317453 and 317454).

In a small subset of individuals, the OKT4 clone does not bind to CD4 due to polymorphisms in CD4.9

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061.
  3. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (FC) PubMed
  4. Cicin-Sain L, et al. 2010. J. Immunol. 184:6739. PubMed
  5. Rosenzweig M, et al. 2001. J. Med. Primatol. 30:36.
  6. Linder J, et al. 1987. Am. J. Pathol. 127:1.
  7. Boche D, et al. 1999. J. Neurovirol. 5:232. (IHC)
  8. Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. USA. 76:4061. (Immunogen)
  9. Lederman S, et al. 1991. Mol Immunol. 28:1171-81.
Product Citations
  1. Soday L, et al. 2021. Frontiers in Immunology. 12:600056. PubMed
  2. Carre C, et al. 2021. iScience. 24:102970. PubMed
  3. Wang T, et al. 2022. Front Immunol. 13:954121. PubMed
  4. Uhlenbrock F, et al. 2014. J Immunol. 193:1654. PubMed
  5. Claiborne DT, et al. 2019. PLoS Pathog. 15:e1007981. PubMed
  6. Mete B, et al. 2022. Life Sci Alliance. 5:. PubMed
  7. Azizi E et al. 2018. Cell. 174(5):1293-1308 e36. PubMed
  8. Want MY, et al. 2019. Oncoimmunology. 8:e1586042. PubMed
  9. Sun J, et al. 2018. Scand J Immunol. 88:e12674. PubMed
  10. Ahmed R et al. 2019. Cell. 177(6):1583-1599 . PubMed
  11. Saadati S, et al. 2020. Avicenna J Med Biotechnol. 0.591666667. PubMed
  12. Zhu ZY, et al. 2022. Front Immunol. 12:781087. PubMed
  13. Dushyanthen S, et al. 2017. Nat Commun. 10.1038/s41467-017-00728-9. PubMed
  14. Wang Z, et al. 2021. Cell Mol Immunol. 18:2188. PubMed
  15. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  16. Acerbi E, et al. 2016. Sci Rep. 6:23128. PubMed
  17. Altman K 2006. J Immunol . 177:1721. PubMed
  18. Li N, et al. 2021. STAR Protoc. 2:100942. PubMed
  19. Bellini N, et al. 2022. iScience. 25:105234. PubMed
  20. Beatson RE, et al. 2021. Cell Rep Med. 2:100473. PubMed
  21. Narsale A, Moya R, Robertson H 2016. Data Brief. 8: 1348-51. PubMed
  22. Sugita S, et al. 2016. Stem Cell Reports. 7:619-634. PubMed
  23. Arif S, et al. 2020. Diabetologia. 63(6):1186-1198.. PubMed
  24. Alsaleh G, et al. 2020. Elife. 9: . PubMed
  25. Jiang H, et al. 2021. Oncoimmunology. 10:1943180. PubMed
  26. Wang A, et al. 2020. Front Immunol. 1.213194444. PubMed
  27. Zhang J, et al. 2022. Nature. 609:369. PubMed
  28. Johnson A, et al. 2016. mSphere. 1: e00288-16. PubMed
  29. Bigler M, et al. 2015. PLoS One. 10: 0145635. PubMed
  30. Berezhnoy A, et al. 2020. Cell Rep Med. 1:100163. PubMed
  31. Jafari M, et al. 2014. J Virol. 88:5062. PubMed
  32. Kim K, et al. 2019. Nat Microbiol. 1.586111111. PubMed
  33. Frencher J, et al. 2014. J Leukoc Biol. 96:957. PubMed
  34. Li N, et al. 2020. Oncoimmunology. 9:1824643. PubMed
  35. Li N, et al. 2021. Cell Rep Med. 2:100297. PubMed
  36. Dahal S, et al. 2022. Retrovirology. 19:18. PubMed
  37. Bossini-Castillo L, et al. 2022. Cell Genom. 2:None. PubMed
  38. Dupont L, et al. 2021. Cell Host Microbe. 29(5):792-805.e6. PubMed
  39. Mishra A, et al. 2021. Cell. 184(13):3394-3409.e20. PubMed
  40. Cirelli KM et al. 2019. Cell. 177(5):1153-1171 . PubMed
  41. Roy S, et al. 2021. Nat Commun. 12:3182. PubMed
  42. Ledderose C, et al. 2021. J Leukoc Biol. 109:497. PubMed
  43. Comte D, et al. 2016. Proc Natl Acad Sci U S A. 113: 9321 - 9326. PubMed
  44. Su Y, et al. 2020. Cell. 1479:183. PubMed
  45. Mujib S, et al. 2017. JCI Insight. 2:e93687. PubMed
  46. Reyes M, et al. 2021. Sci Transl Med. 13:. PubMed
  47. Clayton KL, et al. 2021. Cell Host Microbe. 29(3):435-447.e9. PubMed
  48. Siedlik J, et al. 2017. J Immunol Methods. 10.1016/j.jim.2017.03.017. PubMed
  49. Sashihara J, et al. 2011. PLoS One. 6:e1002308. PubMed
  50. Okutani Y, et al. 2022. Tissue Eng Part A. 28:94. PubMed
  51. Dotson A, et al. 2013. Clin Immunol. 148:149. PubMed
  52. Kang HM, et al. 2018. Nat Biotechnol. 36:89. PubMed
RRID
AB_571944 (BioLegend Cat. No. 317415) AB_571945 (BioLegend Cat. No. 317416)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 55 kD
Distribution

T cell subset, majority of thymocytes, monocytes/macrophages

Function
MHC class II co-receptor, lymphocyte adhesion, thymic differentiation, HIV receptor
Ligand/Receptor
MHC class II molecules, HIV gp120, IL-16
Cell Type
Macrophages, Monocytes, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Center D, et al. 1996. Immunol. Today 17:476.
2. Gaubin M, et al. 1996. Eur. J. Clin. Chem. Clin. Biochem. 34:723.

Gene ID
920 View all products for this Gene ID
UniProt
View information about CD4 on UniProt.org
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