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產(chǎn)品編號	bs-4597R
英文名稱	Rabbit　Anti-MMP-1　antibody
中文名稱	基質(zhì)金屬蛋白酶-1抗體
別　　　　名	MMP-1; MMP1; CLGN; CLG; collagenase, fibroblast; Fibroblast collagenase; Interstitial collagenase; Matrix metallopeptidase 1 (interstitial collagenase); Matrix metalloprotease 1; Matrix metalloproteinase-1; Matrix Metalloproteinase 1; MMP1_HUMAN; OTTHUMP00000045866;MMP 1.
	Specific References　　(10)　　　　　\|　　　　　bs-4597R has been referenced in 10 publications. [IF=6.51]　Woan-Ruoh Lee. et al. Laser-assisted nanoparticle delivery to promote skin absorption and penetration depth of retinoic acid with the aim for treating photoaging. INT J PHARMACEUT. 2022 Nov;627:122162　　WB　;　　Human.　　 PubMed:36122617 [IF=5.606]　Luo Ping. et al. IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway. Rheumatology. 2020 Oct;59(10):3070-3080　　WB　;　　Human.　　 PubMed:32417913 [IF=5.17]　Ou et al. Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals. (2015) Oncotarge. 6:26065-78　　WB　;　　Human.　　 PubMed:26305549 [IF=5.039]　Luo P et al. IL‐37b alleviates inflammation in the temporomandibular joint cartilage via IL‐1R8 pathway. Cell Prolif. 2019 Sep 27:e12692.　　WB&IHC-P　;　　Human&Rat.　　 PubMed:31560411 [IF=4.162]　Wenwen Chen. et al. Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification. Drug Des Dev Ther. 2021; 15: 4125–4140　　IHC　;　　mouse.　　 PubMed:34616145 [IF=4.105]　Ai Jin. et al. TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts. Bba-Mol Cell Res. 2021 Jun;:119083　　IF　;　　Human.　　 PubMed:34147561 [IF=3.71]　Ma, Chuan, et al. (2014) "Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats." PLoS ONE 9(9) (2014):e107544　　WB　;　　Rat.　　 PubMed:25226519 [IF=3.063]　Li W et al. Bevacizumab tested for treatment of knee osteoarthritis via inhibition of synovial vascular hyperplasia in rabbits. Journal of Orthopaedic Translation.2019 April 28.　　IHC-P　;　　Rabbit.　　 PubMed:doi:10.1016/j.jot.2019.04.002 [IF=2.999]　Chen CL et al. miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP 1 and MMP 3 in vitro and in vivo. FEBS Lett. 2019 Apr 12.　　WB　;　　Human.　　 PubMed:30977909 [IF=2.311]　Dezhi Wu. et al. Long non?coding RNA maternally expressed gene?3 affects cell proliferation, apoptosis and migration by targeting the microRNA?9?5p/midkine axis and activating the phosphoinositide?dependent kinase/AKT pathway in hepatocellular carcinoma. Oncol Lett. 2021 May;21(5):1-8　　WB　;　　Human.　　 PubMed:33747202
研究領(lǐng)域	腫瘤　　心血管　　細(xì)胞生物　　信號轉(zhuǎn)導(dǎo)　　細(xì)胞骨架
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human,Mouse,Rat,Rabbit (predicted: Dog,Cow,Horse,Sheep)
產(chǎn)品應(yīng)用	WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	27/41/54kDa
細(xì)胞定位	細(xì)胞外基質(zhì)
性　　　　狀	Liquid
濃　　　　度	1mg/ml
免　疫　原	KLH conjugated synthetic peptide derived from human MMP-1:　251-350/469
亞　　　　型	IgG
純化方法	affinity purified by Protein A
緩　沖　液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產(chǎn)品介紹	The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. Function: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Subunit: Interacts with HIV-1 Tat. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: P03956 Gene ID: 4312 Database links: Entrez Gene: 4312　Human Entrez Gene: 17386　Mouse Entrez Gene: 397320　Pig Entrez Gene: 100009110　Rabbit Omim: 120353　Human SwissProt: P28053　Cow SwissProt: P03956　Human SwissProt: P33435　Mouse SwissProt: P21692　Pig SwissProt: P13943　Rabbit Unigene: 83169　Human 基質(zhì)金屬蛋白酶(matrix metalloproteinases, MMPs)是一族依賴鋅離子而降解各種細(xì)胞外基質(zhì)的蛋白酶，亦稱IV型膠原酶或稱明膠酶A，其主要功能為降解IV型膠原，因而它在腫瘤細(xì)胞突破基底膜屏障和浸潤轉(zhuǎn)移中起重要作用。目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測與腫瘤轉(zhuǎn)移浸潤的研究。
產(chǎn)品圖片	Sample: HL-60 Cell (Human) Lysate at 30 ug Primary: Anti-MMP-1 (bs-4597R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 55/48 kD Sample: heart (Mouse) Lysate at 40 ug Primary: Anti-MMP-1 (bs-4597R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 55/48 kD Sample: Lane 1: Testis (Rat) Lysate at 40 ug Lane 2: Testis (Mouse) Lysate at 40 ug Primary: Anti-MMP-1 (bs-4597R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 54 kD Sample: Spleen (Rabbit) Lysate at 40 ug Primary: Anti-MMP-1 (bs-4597R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution Predicted band size: 24/54 kD Observed band size: 25 kD Paraformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human cervical carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MMP-1) Polyclonal Antibody, Unconjugated (bs-4597R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.