| 產品編號 | bs-1184P |
| 英文名稱 | TRAF6 Antibody Blocking Peptide |
| 中文名稱 | 腫瘤壞死因子受體相關因子6封閉多肽 |
| 別 名 | TNF receptor-associated factor 6; Interleukin 1 signal transducer; MGC 3310; MGC3310; RING finger protein 85; RNF 85; RNF85; TRAF 6; TRAF-6; TRAF6_HUMAN. |
| 性 狀 | Lyophilized powder |
| 物 種 | mouse |
| 純化方法 | HPLC |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產品介紹 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]. SWISS: P70196 Gene ID: 7189 |
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