| 產(chǎn)品編號 | bs-42060P |
| 英文名稱 | Recombinant human Fibulin 5 protein, C-His |
| 中文名稱 | 重組人衰老關(guān)鍵蛋白 |
| 別 名 | ARMD3; Dance; Developmental arteries and neural crest EGF like protein; FBLN5; FIBL 5; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FBLN5_HUMAN; UP50; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; Urine p50 protein. |
| 理論分子量 | 30kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達系統(tǒng) | E.coli |
| 標簽 | c-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 8M Urea, 5mM DTT |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on chromosome 14 in band 14q32.1. See also: Fibulin 3. May play a role in vascular growth and maturation during development and in lesions of injured vessels. SWISS: Q9UBX5 Gene ID: 10516 Fibulin-5 Fibulin-5亦稱為FBLN-5、DANCE或EVEC是細胞外基質(zhì)蛋白質(zhì)家族的一員，在組織器官發(fā)育、重塑和修復(fù)過程中起重要作用，并與內(nèi)皮細胞相互作用.Fibulin-5廣泛分布于富含彈性蛋白的組織, 能直接與原彈性蛋白結(jié)合,并將后者錨于細胞表面,這對形成彈性纖維十分關(guān)鍵, 對血管的發(fā)育和修復(fù)具有重要作用.此外,Fibuljn-5還能促進創(chuàng)口愈合, 與細胞的增殖、運動和侵襲有關(guān) fibulin-5有學(xué)者稱“皮膚衰老關(guān)鍵蛋白”與皮膚彈性有關(guān)的蛋白，對于起著固定細胞外壁、保持肌膚緊繃、維護肺部和血管柔韌性作用的彈性纖維的發(fā)育十分關(guān)鍵. 還有學(xué)者認為：fibulin-5能夠抑制血管的形成，該蛋白質(zhì)在腫瘤轉(zhuǎn)移過程中表達降低或消失，將有可能用于腫瘤治療方面的研究。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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