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重組人低分子量神經絲蛋白

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產品編號bs-44004P
英文名稱Recombinant human NF-L protein, N-His
中文名稱重組人低分子量神經絲蛋白
別    名Neurofilament L; Neurofilament 68; Neurofilament triplet L; 70 kD Neurofilament Light; 68kDa neurofilament protein; CMT 1F; CMT 2E; CMT1F; CMT2E; FLJ53642; Light molecular weight neurofilament protein; NEFL; Neurofilament light; Neurofilament light polypeptide 68kDa; Neurofilament light polypeptide; Neurofilament protein, light chain; Neurofilament subunit NF L; Neurofilament triplet L protein; NF 68; NF L; NF68; NFL; NFL_HUMAN  
理論分子量52.6kDa
性    狀Lyophilized or Liquid
濃    度>0.5mg/ml
物    種Human
純    度>90% as determined by SDS-PAGE
表達系統E.coli
標簽N-His
緩 沖 液20 mM Tris-HCl (pH=8.0)
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹Neurofilament light polypeptide also called NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions. NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. Belongs to the intermediate filament family.

SWISS:
P07196

Gene ID:
4747

神經生物學相關蛋白(Neurobiology)
低分子量神經絲蛋白,簡稱NF-L,分子量為68kDa,NF-L的聚集與神經退行性疾病的發病機理相關,如運動神經元的降解等。
神經纖絲蛋白的功能是提供彈性使神經纖維易于伸展和防止斷裂。
神經絲是中間纖維的一種重要類型又稱神經微絲蛋白,特異地在神經細胞內表達,并在軸突內相互平行排列成束. 哺乳動物的神經絲由3種蛋白組成:
低分子量神經絲蛋白,簡稱NF-L;分子量為68kDa;
中分子量神經絲蛋白,簡稱NF-M;分子量為160kDa;
高分子量神經絲蛋白,簡稱NF-H,分子量為200 kDa。
產品圖片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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