| 產品編號 | bs-43633P |
| 英文名稱 | Recombinant mouse PD-L1 protein, C-His (HEK293) |
| 中文名稱 | 重組小鼠PD-L1蛋白 |
| 別 名 | CD274; B7 H; B7 H1; B7 homolog 1; B7-H1; B7H; B7H1; CD 274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; OTTHUMP00000021029; PD L1; PD1L1_MOUSE; PD1L1_MOUSE; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL 1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1; RGD1566211 |
| 理論分子量 | 26.8kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Mouse |
| 序 列 | 19-238/290 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內毒素 | Not analyzed |
| 表達系統 | HEK293 cell |
| 標簽 | C-His |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品介紹 | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] SWISS: Q9EP73 Gene ID: 60533 程序性死亡配體1（B7-H1）可以促進上皮細胞的惡性轉化,保護表皮細胞免于失巢凋亡,在腫瘤的發生,進展和轉歸中發揮重要作用. 目前對CD274信號通路的進一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應中T細胞介導的免疫應答調控提供了新的途徑.B7-H1在癌癥、類風濕、HIV感染等疾病中發現B7-H1有負調節作用。對B7-H1路徑進行調控有助于自身免疫病及惡性腫瘤的治療。 |
| 產品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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