| 產(chǎn)品編號(hào) | bs-42341P |
| 英文名稱 | Recombinant human MTOR protein, N-His |
| 中文名稱 | 重組人雷帕霉素靶蛋白 |
| 別 名 | FKBP12; dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FK506 binding protein 12 rapamycin complex associated protein 1; FK506 binding protein12-rapamycin associated protein 1; FK506 binding protein12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; MTOR_HUMAN; OTTHUMP00000001983; RAFT1; Rapamycin and FKBP12 target 1; Rapamycin associated protein FRAP2; Rapamycin target protein 1; Rapamycin target protein; RAPT1; Serine/threonine-protein kinase mTOR. |
| 理論分子量 | 36.1kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 物 種 | Human |
| 序 列 | 1-300/2549 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 2M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression. SWISS: P42345 Gene ID: 2475 mTOR蛋白是一種絲氨酸／蘇氨酸蛋白激酶（Ser/Thr），是調(diào)節(jié)細(xì)胞生長(zhǎng)和增殖的重要信號(hào)轉(zhuǎn)導(dǎo)分子，在細(xì)胞的生長(zhǎng)、分化、增殖、遷移和存活上扮演了重要的角色。由于mTOR信號(hào)通路在細(xì)胞周期進(jìn)程中發(fā)揮了重要作用，細(xì)胞周期進(jìn)程調(diào)節(jié)異常與許多疾病尤其是癌癥的發(fā)生、發(fā)展有關(guān)，mTOR信號(hào)通路的失調(diào)可引起多種腫瘤的發(fā)生。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 85% as determined by reducing SDS-PAGE. |
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