| 產(chǎn)品編號(hào) | bs-43637P |
| 英文名稱 | Recombinant human NGFR protein, C-His (HEK293) |
| 中文名稱 | 重組人神經(jīng)生長(zhǎng)因子受體蛋白 |
| 別 名 | TNR16_HUMAN; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor 1 Publication); p75 ICD; CD271; TNFRSF16; p75NTR; p75(NTR); Gp80-LNGFR; p75 NGF Receptor; |
| 理論分子量 | 25.8kDa |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 物 種 | Human |
| 序 列 | 29-250/427 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 標(biāo)簽 | C-His |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis. SWISS: P08138 Gene ID: 4804 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） NGFR神經(jīng)生長(zhǎng)因子受體又稱：CD271存在與細(xì)胞上的與神經(jīng)生長(zhǎng)因子相結(jié)合并相互作用的蛋白質(zhì)因子，屬一型跨膜TNF受體超家族糖蛋白，它可與NGF, BDNF, NT-3, NT-4 結(jié)合，根據(jù)與神經(jīng)生長(zhǎng)因子的結(jié)合力速度及親和力可分為高親和力和低親和力兩種NGFR。 此抗體識(shí)別分子量為47kDa低親和力的NGFR.NGF-R也稱為低親和神經(jīng)生長(zhǎng)因子受體，屬1型跨膜TNF受體超家族。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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